Webb10 juni 2024 · Abstract. Lactate is an end product of glycolysis. As a critical energy source for mitochondrial respiration, lactate also acts as a precursor of gluconeogenesis and a … Webb12 okt. 2024 · This study may open an avenue for the exploration of a role of neuronal activity-induced lactate mediated by protein lactylation in the brain. Kla induced by exogenous lactate in brain cells ...
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Webb26 okt. 2024 · The lactylated proteins were distributed in multiple compartments and associated with diversified biological processes, which do not have obvious roles in DNA-templated process. Besides, we identified 82 lactylation sites in 43 ribosomal proteins, indicating that Kla is an abundant PTM in the ribosome. Webb27 juni 2024 · Fig. 1: Protein lactylation. A previously unnoticed protein modification on lysine residues by the well-known metabolite lactate proves extensive upon mining public proteomics data repositories ... time warner streaming tv
Frontiers Protein Lactylation Critically Regulates Energy Metabolism
Webb4 mars 2024 · LDHA, HMGB1, lactate and histone lactylation was up-regulated in the OGD/R treated N2a cells. Additionally, LDHA knockdown decreased HMGB1 levels in vitro, and relieved CI/R injury in vivo ... Shoji H, Otabi H, Toyoda A, Katoh K, Namihira M, Miyakawa T (2024) Protein lactylation induced by neural excitation. Cell Rep v 37:109820. Webb12 okt. 2024 · Protein lactylation, a novel post-translational modification, is induced in the brain by neural activation and social stress Peer-Reviewed Publication Fujita Health … Webb7 juni 2024 · In addition to the lactylated peptides, SIRT2 also showed delactylation activity against purified histone proteins and nucleosomes from HeLa cells as detected by immunoblotting using specific... time warner streaming online