WebNational Center for Biotechnology Information WebThe TP53INP1 gene encodes two protein isoforms, TP53INP1α and TP53INP1β. Upon initial DNA damage, p53 is phosphorylated at Ser-15 and Ser-20, stimulating the binding of p53 …

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WebMay 19, 2016 · Luciferase assays with the Pim1 3′-UTR found no decrease by miR-124a . microRNAs miR-33a (a known Pim1 target) 21 and miR-214 (a putative high-seed match to the Pim1 3′UTR), both targeted Pim1 . Although the effects of miR-33a were previously reported, this is the first report demonstrating that miR-214 can directly target the Pim1 … WebJan 31, 2024 · PIM1 is known to phosphorylate AR, which plays a key role in PCa progression. 21, 109 Both PIM1S and PIM1L interact with AR, and differential phosphorylation of AR at multiple sites leads to... hardware shop ross on wye

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WebApr 19, 2024 · RUNX3 nuclear expression was known to promote RUNX3 target genes transcription. We next sought to examine whether PIM1 knockdown could promote the transcription of RUNX3 target gene Cdkn1a (p21). PIM1 knockdown was shown to promote Cdkn1a (p21) transcription in MCF-7, T47D, BT-549 and MDA-MB-231 cells (Figure 6F). WebJul 22, 2007 · PIM protein kinases have been known for some time as oncogenes that promote lymphomagenesis together with MYC (c-Myc). It is now reported that PIM1 is a coactivator of MYC, and it phosphorylates... WebMar 30, 2024 · Although we found that mutations in PIM1, FOXO1 and TMEM30A were associated with an adverse clinical behavior, definitive conclusions cannot be drawn, ... 18 and X; losses: 1p36, 6p21, 6q14, 6q23, 9p21, 10q23, 13q14 and 22q13; and CN-LOH: 1p36, 6p25-p21, 12q13 and 16p13. Using GISTIC, we identified six driver losses (q-value <0.05): ... change of name on property title qld