Human topoisomerase i purchase

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August undefined, 2024

Weball of OUR PRODUCTS are validated & certified by TopoGEN Scientists Topo Kits Showing 1 – 15 of 24 results All Categories Topo Kits Download CSV Sort by 1 2 OUR … Web28 feb. 2024 · DNA topoisomerases are present in all domains of life to resolve a wide variety of topological problems arising from the length of the human double-helix DNA …

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WebHigh purity, catalytically active Human Topoisomerase I overexpressed in the baculovirus system and purified to single band homogeneity. These preparations are cheaper than … WebGet better batch-to-batch reproducibility with a recombinant antibody. Anti-Topoisomerase I antibody [EPR5376 (2)] (ab131166) Research with confidence – consistent and … count lines in powershell

Topoisomerase I - Thermo Fisher Scientific

WebProduct name Recombinant Human Topoisomerase I protein See all Topoisomerase I proteins and peptides Purity > 95 % SDS-PAGE. Purified by using an affinity column and … Web23 apr. 2003 · Human topoisomerase I is a 765-aa (91-kDa) enzyme that catalyzes the relaxation of both negative and positive supercoils in a reaction that does not depend on an energy-rich cofactor or divalent cations ( 1 ). Based on limited proteolysis studies and the crystal structure ( 6, 7 ), the protein can be divided into four discrete domains. WebHigh purity, catalytically active Human Topoisomerase I overexpressed in the baculovirus system and purified to single band homogeneity. These preparations are cheaper than native top1 made from human tissue and offer excellent purity and high specific activity. count lines in scanner in java

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RCSB PDB - 1T8I: Human DNA Topoisomerase I (70 Kda) In …

Web1 mrt. 2000 · Human topoisomerase I helps to control the level of DNA supercoiling in cells and is vital for numerous DNA metabolic events, including replication, transcription, and recombination. The 2.6 A crystal structure of human topoisomerase I in noncovalent complex with a DNA duplex containing a cytosine at the -1 position of the scissile strand … Web23 jan. 2024 · Recent advances in the field have suggested a possibility of designing isoform-specific human topoisomerase II poisons, which may be developed as safer anticancer drugs. It may also be possible to design catalytic inhibitors of topoisomerases by targeting certain inactive conformations of these enzymes. count lines in text file c#WebRegister today to view list prices and apply for an account to purchase online! ... IHC Primary Antibodies • Topoisomerase I; Human tonsil: immunohistochemical staining for Topoisomerase I. Note nuclear staining of ... Human Topoisomerase I is a 100 kD protein capable of relaxing positively and negatively supercoiled DNA by performing a ... brentwood street grocery

"WebCovers a wide range of assays from cell-based methods and molecular analysis of topoisomerases, to biochemical and biophysical studies Presents diverse approaches to experimental design, covering model biological systems including yeast and mammalian cells as well as cell-free systems and purified components " - Human topoisomerase i purchase

Human topoisomerase i purchase

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Web9 okt. 2024 · DNA topoisomerases 1 and 2 are enzymes that maintain DNA topology and play important essential genome functions, including DNA replication and transcription. Aberrant topoisomerases cause genome instability and a wide range of diseases, cancer in particular. Both Topo 1 and 2 are the targets of valuable anticancer drugs, such as … WebTopo Antibodies - TopoGEN all of OUR PRODUCTS are validated & certified by TopoGEN Scientists Topo Antibodies Showing 1 – 15 of 16 results All Categories Topo Antibodies …

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Web16 feb. 2024 · Antibacterial resistance has become one of the most serious problems threating global health. To overcome this urgent problem, many scientists have paid great attention to developing new antibacterial drugs from natural products. Hence, for exploring new antibacterial drugs from Chinese medicine, a series of experiments were carried out … WebHuman topoisomerase 1B regulates the topological state of supercoiled DNA enabling all fundamental cell processes. This enzyme, which is the unique molecular target of the natural anticancer compound camptothecin, acts by nicking one DNA strand and forming a transient protein–DNA covalent complex. The interaction of human topoisomerase 1B and …

WebProduct ID: topoisomerase-i Antigen Background Topoisomerases are nuclear enzymes involved in a variety of cellular activities such as chromosomal condensation, DNA … Web29 mrt. 2024 · Topoisomerase: A class of enzymes that alter the supercoiling of double-stranded DNA. (In supercoiling the DNA molecule coils up like a telephone cord, which …

WebTopoisomerases constitute a family of highly conserved essential enzymes, which exist in all investigated living pro- and eukaryotic cells. They are indispensable for the control of … WebSince human topoisomerase I plays an important role in HIV-1 replication and infectivity, it may become an important pharmacological target for the antiHIV therapy Shoya et al (2003). View chapter Purchase book. Read full chapter.

Web12 mei 2004 · Human DNA Topoisomerase I (70 Kda) In Complex With The Poison Camptothecin and Covalent Complex With A 22 Base Pair DNA Duplex PDB DOI: 10.2210/pdb1T8I/pdb NDB: PD0549 Classification: ISOMERASE/DNA Organism (s): Homo sapiens Expression System: Spodoptera frugiperda Mutation (s): Yes Deposited: 2004 …

Web9 feb. 2012 · Topoisomerase II resolves intrinsic topological problems of double-stranded DNA. As part of its essential cellular functions, the enzyme generates DNA breaks, but the regulation of this potentially dangerous process is not well understood. brentwood street portland maineWebDNA Topoisomerase-I Human Recombinant produced in SF9 is a glycosylated, polypeptide chain having a molecular mass of 102 kDa. The TOP1 is expressed with a … count lines in text file javaWeb18 mrt. 2024 · During the last years, renewable energy strategies for sustainable development perform as best practices and strategic insights necessary to support large scale organizations’ approach to sustainability. Power purchase agreements (PPAs) enhance the value of such initiatives. A renewable PPA contract delivers green energy … brentwood street high pointWeb20 okt. 2005 · Abstract. Human topoisomerase I (htopoI) is an enzyme that up to now was believed to function mainly in the removal of torsional stress generated during transcription and replication. In 1998, it was found that htopoI might play another important role in the cellular response to DNA damage -- the so-called htopoI damage response. brentwood stretchlab brentwood stroller u pickWebHuman Topoisomerase I Assay Kit contains all the necessary reagents for routine detection of Topoisomerase I activity. The included DNA markers allow unequivocal … count lines in text file pythonWebRabbit mAb (BSA and Azide Free) #27498. Flow cytometric analysis of Jurkat cells using Topoisomerase IIα (D10G9) XP ® Rabbit mAb compared to concentration-matched Rabbit (DA1E) mAb IgG XP ® Isotype Control #3900 (red). Anti-rabbit IgG (H+L), F (ab') 2 Fragment (Alexa Fluor ® 488 Conjugate) #4412 was used as a secondary antibody. count lines of code in a repo