WebFeb 5, 2008 · Fimbrin (called plastin in humans) is involved in actin bundle formation in microvilli and stereocilia, and is composed of two actin binding domains (ABD1 and ABD2), each containing tandem CH-domains. A model of actin-fimbrin bundles ( 5) assumed that ABD2 interacts with actin filaments in the same manner observed for ABD1 ( 2 ). WebFimbrin represents one of the most basic structures of an actin crosslinking protein; it contains a calcium-binding domain consisting of a pair of EF hand domains, and a pair of actin binding domains (ABDs) composed of two …
Unidirectional cooperative binding of fimbrin actin-binding
WebActin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed: 29581253 ). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed: 29581253 ). Fimbrin is present in several distinct structures in different cell types, including intestinal microvilli, hair cell stereocilia and fibroblast filopodia. It is usually associated with polarized actin filaments in membrane ruffles, filopodia, stereocilia and adhesion plaques. Sequence homology and biochemical properties show that fimbrin is highly conserved from yeast to humans. Yeast mutants lacking fimbrin are defective in morphogenesis and endocytosis. good american black bodysuit
Plastin 3 in health and disease: a matter of balance
WebIn chemistry, acetylation is an organic esterification reaction with acetic acid. It introduces an acetyl group into a chemical compound. Such compounds are termed acetate esters or simply acetates. Deacetylation … WebAbstract. Fimbrin is a cytoskeletal protein associated with microfilaments in microvilli, microspikes, stereocilia, membrane ruffles, and cell--substratum attachment sites. … WebOct 3, 2016 · Yeast fimbrin is encoded by the SAC6 gene, mutations of which suppress temperature-sensitive mutations in the actin gene (ACT1). To examine the mechanism of … good american belted shirt jacket