WebMMAE is a highly potent auristatin (free drug IC50: 10−11-10−9 M) developed by Seattle Genetics. This cytotoxic molecule represents as much as 100 to 1000 folds more potent than the standard chemotherapeutic drugs such as vinblastine10,11. However, MMAE, as well as MMAF, is currently being used as payloads in WebDec 10, 2024 · After MMAE conjugation to albumin, the IC50 of ALDC1 and ALDC3 was higher than free MMAE, exhibiting μM toxicity in MIA PaCa-2 and PANC1 cells (Fig. 5 B and C). Of note, the IC50 for ALDC1 in MIA PaCa2 cells at 24 h is 2.68 μM, while it is 20.7 μM in HUVEC cells; there is about a 10-fold difference that suggests cell specific uptake.
Dxd ≥99%(HPLC) DNA topoisomerase I inhibitor AdooQ®
WebMay 11, 2024 · Triple negative breast cancer (TNBC) is a heterogeneous tumor subtype conventionally defined by the absence of expression of the estrogen receptor (ER), progesterone receptor (PgR), and human epidermal growth factor receptor 2 (HER2) amplification, and accounts for approximately 15–20% of all breast carcinomas.Clinically, … WebDxd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a). For research use only. We do not sell to … simpson maxidry 10s capacity
Monomethyl auristatin antibody and peptide drug conjugates for …
WebNov 7, 2024 · Results In vitro, treatment of human PBMCs with free DXd caused anti-proliferative effects (IC50 = 0.06uM); however, conjugation of DXd to trastuzumab (T-DXd IC50 = 60ug/mL) mitigated the... WebHere, we describe a potent MMAE-linked antibody-drug conjugate (ADC) targeting tumor endothelial marker 8 (TEM8, also known as ANTXR1), a highly conserved transm... Cite Contexts in source... WebApr 10, 2024 · Additionally, the IC50 value of trastuzumab deruxtecan was calculated in 63.3% (n = 30/49) of cell lines, while the IC50 value of trastuzumab was calculated in 1 cell line (NCI-N87). Notably, the cell lines with HER2 overexpression and non-expression proved to be sensitive to the ADC (P <.0001). simpson mass timber connectors