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WebMar 23, 2024 · What causes mouth ulcers? In many cases, the reason for mouth ulcers is unclear. Most single mouth ulcers are caused by damage to the lining inside of the mouth. For example: accidentally biting the inside of your cheek or a sharp tooth; poorly fitting dentures; hard food; a defective filling WebA mouth ulcer is a sore that develops in the soft tissue lining of your gums, tongue, inner cheeks, lips or palate. They’re usually yellow or red, and they can be quite painful. … WebFeb 27, 2024 · Methotrexate naturally occurs in your body and increasing the levels with medication containing this substance is known to cause mouth ulcers. 2 . A possible side effect of taking prescription methotrexate is mucositis, inflammation of the lining of your mouth. Patients taking high doses are even more susceptible. dfw to lhr flight schedule